Insulin-like Growth Factor – benefits and side effects


Insulin-like growth factor-1 is otherwise referred as IGF-1. This is a polypeptide hormone belonging to the family of growth factor hormone. IGF-1 is naturally produced in the human liver, peripheral tissues. However, man-made versions of IGF-1 are available and this is produced by recombinant DNA technology.

This is an extremely anabolic hormone which affects many parts of the human body. Insulin Growth Factor has a bond with human growth hormone and it is similar to insulin on the structural basis. Though there are several synthetic version of IGF-1 is present in the market, the popular one is Increlex by Tercia INC.

The Synthetic version of IGF-1 helps to treat IGF-1 deficiencies. Patients who do not respond to human growth hormone for medical reasons are treated with Insulin Growth factor-1. Though IGF-1 is FDA approved, still some medical professionals think about the metabolic effects. Besides, this synthetic version has been used as a performance-enhancing drug nowadays. IGF-1 is attracted by the bodybuilders due to its anabolic properties.

The Main Function of IGF-1

The specific trait of IGF-1 is NOT MOVING GLUCOSE INTO CELLS as in Insulin. The cellular division and growth are supported by IGF-1. Insulin Growth Factor-1 also helps to repair the brain, heart and muscle cells. That’s why most of the people run behind it. Heart attack risks are higher at the people who have decreased levels of IGF-1.

IGF-1 profile in muscle building

IGF-1 increases glycogen synthesis and supports a deep training among athletes and bodybuilders. In human, two types of IGF-1 are produced in muscles. Mechano Growth Factor is a primary one which benefits from massive muscle gain. MG factor triggers various protein activities that are involved in muscle protein synthesis. Besides, it also pushes the activity of muscle stem cells. These cells are otherwise called satellite cells which predominantly repair the damaged muscle. Intense training will stimulate the IGF-1 release into the muscles. So, bodybuilders, athletes use IGF-1 synthetic versions for muscle building and recovery. Protein Myostatin is another one which prevents muscle growth by forming hurdles against the satellite cell propagation.

IGF-1 supplements purpose

HGH, a complex protein is secreted by the master gland, the Pituitary to stimulate tissue and nerve growth throughout the body. IGF-1 is a by-product that targets the cell division which in turn leads to the muscle tissue expansion. This property is quite helpful for growing children. While doing strenuous workouts the body gets injured. Micro-tears in the muscles accompany with the strenuous effort and pressure. To cure such tears, GH is produced in higher level and transported to the injured area. It generates rapid muscle growth to stop further damage. IGF-1 is the top supplement choice who wishes for an increased muscle size.

IGF-1 side effects

Though it helps in testosterone production, boosting muscle and bone strength rapidly, IGF-1 produces some unpleasant side effects with long-term usage. Testicles shrinkage, Problems in reproduction, Eating disorders, Dependency, and addiction, increased organs growth, Mood disorders, Tremors, Palpitation, Slurred speech, Perspiration, Hunger, and Drowsiness are some of the major ill effects.


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